Ammonia → 4-amino-1-benzyl-3-nitro-1H-pyridin-2-one

HRID 2214448ノート

反応式

HRID 2214448 の反応式
[NH3:1].[CH2:2]([N:9]1[CH:14]=[CH:13][C:12](OCC2C=CC=CC=2)=[C:11]([N+:23]([O-:25])=[O:24])[C:10]1=[O:26])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>ClCCl>[NH2:1][C:12]1[CH:13]=[CH:14][N:9]([CH2:2][C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=2)[C:10](=[O:26])[C:11]=1[N+:23]([O-:25])=[O:24]

参加物

4

反応物 2

HCID 222AmmoniaHCID 219476521-Benzyl-4-benzyloxy-3-nitro-pyridin-2-one

生成物 1

HCID 219476414-amino-1-benzyl-3-nitro-1H-pyridin-2-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

20 ml of a saturated ethanolic ammonia solution were added to a solution of 5.5 g (16.3 mmol) of 1-benzyl-4-benzyloxy-3-nitro-pyridin-2-one in 50 ml dichloromethane and stirred for 3 days at ambient temperature in the sealed flask. The solution was evaporated to dryness, the residue was triturated with diethyl ether, suction filtered and dried.

後処理

  1. customThe solution was evaporated to dryness
  2. customthe residue was triturated with diethyl ether, suction
  3. filtrationfiltered
  4. customdried

出典と根拠

ORDレコード
ord-acf982725c804f048c9961e2e0d4844a
出典データセット
uspto-grants-2006_09
特許番号
US07109192B2

反応ノート

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