Formaldehyde → 4-Hydroxy-1-[1-hydroxymethyl-2-(1H-indol-3-yl)-ethyl]-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid (3,4-dichloro-benzyl)-methyl-amide

関与物質

反応手順

Compound 768 was prepared from N-(3,4-dichloro-benzyl)-2-(2,2-dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-N-methyl-acetamide, paraformaldehyde and 2-amino-3-(1H-indol-3-yl)-propan-1-ol according to the procedures described for compound 86-A and compound 767. The title compound was isolated as a yellow solid (0.0038 g, 8% yield). 1HNMR (300 MHz, CDCl3) δ: 7.52 (1H, d, J=8.05 Hz), 7.36–7.29 (3H, m), 7.14–6.98 (4H, m), 4.46 (2H, s), 4.40–4.36 (1H, m), 3.99 (2H, s), 3.81–3.78 (2H, m), 3.11–3.08 (3H, m), 2.85 (3H, s).

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