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Methyl iodide → 1-Acetyl-6-bromo-5-methoxyindoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-(6-Bromo-5-hydroxy-2,3-dihydro-1H-indol-1-yl)ethan-1-one | HCID 21948380 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-Acetyl-6-bromo-5-methoxyindoline | HCID 21948375 | 88.1% |
反応手順
A stirred solution of 1-acetyl-6-bromoindolin-5-ol (Tetrahedron 1973, 29(8), 1115; 40 g, 0.15 mole) in DMF (500 ml) was treated with K2CO3 (61 g, 0.45 mole) and iodomethane (11.7 ml, 0.19 mole) and maintained at room temperature for 20 h, then concentrated under vacuum to 200 ml. The residue was treated with water (200 ml) and the precipitate filtered off, dried and recrystallised from EtOAc to afford the title compound as a white solid (35.7 g, 85%). MH+ 270/272.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07109201B2 |
| 出典データセット | uspto-grants-2006_09 |
| ORD ID | ord-5f997226f28c48008664d4de881b219d |
| 出典メモ | uspto-grants-2006_09 |