Benzoyl isothiocyanate → (6-Methoxy-pyrazin-2-yl)-thiourea

HRID 2214764ノート

反応式

HRID 2214764 の反応式
[CH3:1][O:2][C:3]1[N:8]=[C:7]([NH2:9])[CH:6]=[N:5][CH:4]=1.C([N:18]=[C:19]=[S:20])(=O)C1C=CC=CC=1>C(O)C>[CH3:1][O:2][C:3]1[N:8]=[C:7]([NH:9][C:19]([NH2:18])=[S:20])[CH:6]=[N:5][CH:4]=1

参加物

4

反応物 2

HCID 68284Benzoyl isothiocyanateHCID 48681936-Methoxypyrazin-2-amine

生成物 1

HCID 21948402(6-Methoxy-pyrazin-2-yl)-thiourea

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

6-Methoxy-pyrazin-2-ylamine (0.85 g, 6.8 mmol) is dissolved in ethanol (7 ml) and benzoylisothiocyanate (0.91 ml) is added dropwise. The mixture is heated to 80° C. with stirring for 10 minutes then allowed to cool to room temperature. The solvent is removed in vacuo and the resulting solid dissolved in 1M sodium hydroxide (15 ml) and heated under reflux for 1 hour. The resultant suspension is filtered and the solid washed with water and a little cold ethanol. The solid is dried in vacuo to yield the title compound.

後処理

  1. temperatureto cool to room temperature
  2. customThe solvent is removed in vacuo
  3. dissolutionthe resulting solid dissolved in 1M sodium hydroxide (15 ml)
  4. temperatureheated
  5. temperatureunder reflux for 1 hour
  6. filtrationThe resultant suspension is filtered
  7. washthe solid washed with water
  8. customThe solid is dried in vacuo

出典と根拠

ORDレコード
ord-8047c569232c418e9e7ea9481324df5a
出典データセット
uspto-grants-2006_09
特許番号
US07109202B2

反応ノート

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