Water → HCID 178496106、化合物

HRID 2214970

反応式

HRID 2214970 の反応式
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH2:17][CH2:18][O:19][CH3:20])=[CH:12][CH:11]=2)[C:5]([C:21]#[N:22])=[C:4]([SH:23])[N:3]=1.[C:24](=O)(O)[O-].[Na+].ClC[C:31]1[N:32]=[C:33]([C:36]2[CH:40]=[CH:39][S:38][CH:37]=2)[S:34][CH:35]=1.O>CN(C=O)C>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:11]=[CH:12][C:13]([O:16][CH2:17][CH2:18][O:19][CH3:20])=[CH:14][CH:15]=2)[C:5]([C:21]#[N:22])=[C:4]([SH:23]([C:31]2[N:32]=[C:33]([C:36]3[CH:40]=[CH:39][S:38][CH:37]=3)[S:34][CH:35]=2)[CH3:24])[N:3]=1

参加物

6

反応物 4

HCID 962WaterHCID 516892Sodium BicarbonateHCID 6021074-(Chloromethyl)-2-(thiophen-3-yl)-1,3-thiazoleHCID 178496105HCID 178496105、化合物

生成物 1

HCID 178496106HCID 178496106、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

100 mg (0.31 mmol) of 2-amino-4-[4-(2-methoxyethoxy)phenyl]-6-sulphanyl-pyridine-3,5-dicarbonitrile are dissolved in 1 ml of DMF. 103 mg (1.23 mmol) of sodium bicarbonate and 96.4 mg (0.46 mmol) of 4-chloromethyl-2-(thiophen-3-yl)-1,3-thiazole are then added. The suspension is shaken at RT overnight, and water is added. The precipitate is filtered off with suction, washed with ethanol and diethyl ether and dried at 40° C. under reduced pressure. This gives 141 mg (82% of theory) of product.

後処理

  1. filtrationThe precipitate is filtered off with suction
  2. washwashed with ethanol and diethyl ether
  3. customdried at 40° C. under reduced pressure

出典と根拠

ORDレコード
ord-569f1ae26e884bb18752602897058329
出典データセット
uspto-grants-2006_09
特許番号
US07109218B2

関連ノート

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