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Phosgene → Methyl 2-oxooxazolidine-4-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosgene | HCID 6371 | — |
| 反応物 | L-Serine, methyl ester, hydrochloride (1:1) | HCID 2723730 | — |
| 反応物 | HCID 178454970 | HCID 178454970 | — |
| 生成物 | Methyl 2-oxooxazolidine-4-carboxylate | HCID 500251 | — |
反応手順
The preparation of 1-1 was carried out according to the literature procedure (see: Sibi, M. P. et al, J. Chem. Soc. Perkin Trans. 1 1994, 1675). Thus, 39.5 grams of serine methyl ester hydrochloride was reacted with phosgene (20% solution in toluene, 175 mL) to give 42 grams of desired product. 1H NMR (400 MHz, acetone-d6): δ 7.1 (br s, 1H, NH), 4.64–4.56 (m, 2H), 4.44 (dd, 1H), 3.77 (s, 3H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07109223B2 |
| 出典データセット | uspto-grants-2006_09 |
| ORD ID | ord-3fdd557e92d0439d88e25cfc3b72aaf9 |
| 出典メモ | uspto-grants-2006_09 |