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Hydrochloric Acid → (R)-7-[3-amino-4-(2,4,5-trifluoro-phenyl)-butyryl]-8-methyl-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid methyl ester hydrochloride

HRID 221510
ノート
印刷プレビュー

反応式

HRID 221510 の反応式
[CH3:1][O:2][C:3]([C:5]1[N:6]=[C:7]([C:37]([F:40])([F:39])[F:38])[N:8]2[CH2:13][CH2:12][N:11]([C:14](=[O:35])[CH2:15][CH:16]([NH:27]C(OC(C)(C)C)=O)[CH2:17][C:18]3[CH:23]=[C:22]([F:24])[C:21]([F:25])=[CH:20][C:19]=3[F:26])[C@H:10]([CH3:36])[C:9]=12)=[O:4].[ClH:41]>C(OCC)(=O)C>[ClH:41].[CH3:1][O:2][C:3]([C:5]1[N:6]=[C:7]([C:37]([F:40])([F:38])[F:39])[N:8]2[CH2:13][CH2:12][N:11]([C:14](=[O:35])[CH2:15][CH:16]([NH2:27])[CH2:17][C:18]3[CH:23]=[C:22]([F:24])[C:21]([F:25])=[CH:20][C:19]=3[F:26])[C@H:10]([CH3:36])[C:9]=12)=[O:4]
参加物実験手順後処理出典と根拠反応ノート

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 57518482(R)-7-[3-tert-Butoxycarbonylamino-4-(2,4,5-trifluoro-phenyl)-butyryl]-8-methyl-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid methyl ester

生成物 1

HCID 86646929(R)-7-[3-amino-4-(2,4,5-trifluoro-phenyl)-butyryl]-8-methyl-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid methyl ester hydrochloride収率 100%

試薬・触媒・溶媒 1

HCID 8857
Ethyl Acetate
溶媒

実験手順

(R)-7-[3-tert-Butoxycarbonylamino-4-(2,4,5-trifluoro-phenyl)-butyryl]-8-methyl-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid methyl ester 39d (0.23 g, 0.4 mmol) was added into the reaction flask. A solution of 2.3 N hydrochloric acid in 5 mL of ethyl acetate was then added to the flask. The reaction mixture was stirred at room temperature for 2 hours and monitored by thin layer chromatography until the disappearance of the starting materials. The reaction mixture was concentrated under reduced pressure to obtain the title compound (R)-7-[3-amino-4-(2,4,5-trifluoro-phenyl)-butyryl]-8-methyl-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid methyl ester hydrochloride 39 (0.205 g, yield 100%) as a white solid.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-4068cf14d21f48ffb10f3e873683ed8e
出典データセット
uspto-grants-2012_06
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08207161B2

反応ノート

読み込み中…

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