Potassium Carbonate → 1-(3-bromophenyl)-2,5-dihydro-1H-pyrrole
反応式
CS(O[CH2:6]/[CH:7]=[CH:8]\[CH2:9]OS(C)(=O)=O)(=O)=O.[Br:15][C:16]1[CH:17]=[C:18]([CH:20]=[CH:21][CH:22]=1)[NH2:19].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Br:15][C:16]1[CH:17]=[C:18]([N:19]2[CH2:9][CH:8]=[CH:7][CH2:6]2)[CH:20]=[CH:21][CH:22]=1参加物
5
実験手順
Then, a mixture of 15 g of the cis-1,4-bis(methanesulfonyloxy)-2-butene, 10 g of 3-bromoaniline, 24 g of anhydrous potassium carbonate and 70 ml of N,N-dimethylformamide was stirred at room temperature overnight. The reaction mixture was extracted with ethyl acetate-water, and the organic layer was washed with water and brine, dried over anhydrous magnesium sulfate and then evaporated. The residue was purified by silica gel column chromatography with 5% ethyl acetate/hexane, to give 6.6 g of the title compound.
後処理
- extractionThe reaction mixture was extracted with ethyl acetate-water
- washthe organic layer was washed with water and brine
- dry with materialdried over anhydrous magnesium sulfate
- customevaporated
- customThe residue was purified by silica gel column chromatography with 5% ethyl acetate/hexane
出典と根拠
- ORDレコード
- ord-e1e4bcd2a4024edabdae7d4ba268d923
- 出典データセット
- uspto-grants-2006_09
- 特許番号
- US07112593B2
反応ノート
読み込み中…