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1-(1-Ethynylcyclohexyl)piperidine → 1-[1-[2-Benzyl-6-[(3R,4R)-3-hydroxy-4-methoxypyrrolidin-1-yl]-3-pyridyl]ethynylcyclohexyl]piperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(1-Ethynylcyclohexyl)piperidine | HCID 305916 | — |
| 反応物 | 2-Benzyl-3-iodo-6-[(3R,4R)-3-hydroxy-4-methoxypyrrolidin-1-yl]pyridine | HCID 11384307 | — |
| 生成物 | 1-[1-[2-Benzyl-6-[(3R,4R)-3-hydroxy-4-methoxypyrrolidin-1-yl]-3-pyridyl]ethynylcyclohexyl]piperidine | HCID 10140281 | — |
反応手順
This was synthesized in the same manner as in Example 6 except that 2-benzyl-3-iodo-6-[(3R,4R)-3-hydroxy-4-methoxypyrrolidin-1-yl]pyridine (Production Example 1) and 1-(1-ethynylcyclohexyl)piperidine (Production Example 18) were used.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07112593B2 |
| 出典データセット | uspto-grants-2006_09 |
| ORD ID | ord-963d441d0ddc4828b20bf30088adc23c |
| 出典メモ | uspto-grants-2006_09 |