Water → HCID 21058041、化合物

HRID 2216402ノート

反応式

HRID 2216402 の反応式
[NH2:1][C:2]1[C:6]2[CH:7]=[CH:8][C:9]([O:11][CH3:12])=[CH:10][C:5]=2[O:4][C:3]=1[C:13]([NH:15][C:16]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][C:17]=1[Cl:23])=[O:14].ClS([N:28]=[C:29]=[O:30])(=O)=O.O>ClCCl>[Cl:23][C:17]1[CH:18]=[C:19]([Cl:22])[CH:20]=[CH:21][C:16]=1[NH:15][C:13]([C:3]1[O:4][C:5]2[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:6]=2[C:2]=1[NH:1][C:29]([NH2:28])=[O:30])=[O:14]

参加物

5

反応物 3

HCID 962WaterHCID 70918Chlorosulfonyl isocyanateHCID 21058038HCID 21058038、化合物

生成物 1

HCID 21058041HCID 21058041、化合物収率 29.7%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

3-Amino-N-(2,4-dichlorophenyl)-6-methoxybenzofuran-2-carboxamide ¼ hydrate (0.9 g) obtained in Example 1 was dissolved in dichloromethane (10 ml) and chlorosulfonyl isocyanate (0.4 g) was added under ice-cooling. The mixture was further stirred at room temperature for 1 hr. Then water was added and the precipitated crystals were recrystallized from water-containing dimethylformamide to give the title compound (0.3 g). melting point: >260° C.

後処理

  1. temperaturecooling
  2. customthe precipitated crystals were recrystallized from water-
  3. additioncontaining dimethylformamide

出典と根拠

ORDレコード
ord-c356b5dc86f84d6ebf63100d4e887da5
出典データセット
uspto-grants-2006_09
特許番号
US07112594B2

反応ノート

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