Iodine → HCID 49796119、化合物

HRID 2217324ノート

反応式

HRID 2217324 の反応式
[C:1]1(=O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[NH2:11][C:12]([NH2:14])=[S:13].[I:15]I>>[IH:15].[S:13]1[C:2]2[CH2:3][C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][C:9]=3[C:1]=2[N:11]=[C:12]1[NH2:14]

参加物

4

反応物 3

HCID 807IodineHCID 67351-IndanoneHCID 2723790Thiourea

生成物 1

HCID 49796119HCID 49796119、化合物収率 63.6%

反応条件

温度
95 °C

実験手順

A mixture of 1-indanone (6.00 g; 45.4 mmol), thiourea (6.92 g; 90.8 mmol) and iodine (11.52 g; 45.4 mmol) was heated to 95° C. with stirring. After 3 hours, the mixture was allowed to cool to room temperature. The crude solid was triturated with absolute ethanol and filtered. The light yellow solid was washed twice with absolute ethanol then allowed to air dry to provide 9.13 g of 8H-Indeno[1,2-d]thiazol-2-ylamine hydroiodide 1a.

後処理

  1. temperatureto cool to room temperature
  2. customThe crude solid was triturated with absolute ethanol
  3. filtrationfiltered
  4. washThe light yellow solid was washed twice with absolute ethanol
  5. customto air dry

出典と根拠

ORDレコード
ord-ac00b36fa8e340249cdc3ae5fd4976e4
出典データセット
uspto-grants-2008_08
特許番号
US07407977B2

反応ノート

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