Iodine → HCID 49796118、化合物
反応式
[C:1]1(=O)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[NH2:12][C:13]([NH2:15])=[S:14].[I:16]I>O>[IH:16].[N:12]1[C:1]2[C:10]3[C:5]([CH2:4][CH2:3][C:2]=2[S:14][C:13]=1[NH2:15])=[CH:6][CH:7]=[CH:8][CH:9]=3参加物
5
反応条件
- 温度
- 95 °C
実験手順
A mixture of 1-tetralone (5.00 mL; 37.6 mmol), thiourea (5.72 g; 75.2 mmol) and iodine (9.54 g; 37.6 mmol) were heated to 95° C. with stirring. After 4 hr., the mixture solidified and was allowed to cool to room temperature. The mixture was diluted with 200 mL of water and the solid material was filtered off and triturated with absolute ethanol. The solid was washed several times with absolute ethanol to provide 4.00 g of 4,5-Dihydro-naphtho[1,2-d]thiazol-2-ylamine hydroiodide 15 as an off white powder.
後処理
- temperatureto cool to room temperature
- filtrationthe solid material was filtered off
- customtriturated with absolute ethanol
- washThe solid was washed several times with absolute ethanol
出典と根拠
- ORDレコード
- ord-8400d2858c2a4accad689fb42cc8935b
- 出典データセット
- uspto-grants-2008_08
- 特許番号
- US07407977B2
反応ノート
読み込み中…