Ethyl 4-piperidinecarboxylate → 6-Chloro-2-[4-(ethoxycarbonyl)-1-piperidinyl]-5-quinolinecarboxylic acid
反応式
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:8]([C:12]([OH:14])=[O:13])=[C:7]([Cl:15])[CH:6]=[CH:5][C:4]=2[N:3]=1.[NH:16]1[CH2:21][CH2:20][CH:19]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH2:18][CH2:17]1>>[Cl:15][C:7]1[CH:6]=[CH:5][C:4]2[N:3]=[C:2]([N:16]3[CH2:21][CH2:20][CH:19]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH2:18][CH2:17]3)[CH:11]=[CH:10][C:9]=2[C:8]=1[C:12]([OH:14])=[O:13]参加物
3
実験手順
Prepared according to the method of example 30, using 2,6-dichloro-5-quinolinecarboxylic acid (Example 76(b)) (800 mg) and 4-piperidinecarboxylic acid, ethyl ester (2.7 g). Purification (Varian NH2 cartridge using methanol (100 mL) and then 2% acetic acid in methanol (100 mL) as eluant) afforded the title compound as a solid (900 mg).
後処理
- customPrepared
- customPurification (Varian NH2 cartridge