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Ethyl 4-piperidinecarboxylate → Ethyl 1-(5-amino-6-chloroquinolin-2-yl)piperidine-4-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 4-piperidinecarboxylate | HCID 70770 | — |
| 反応物 | 2,6-Dichloroquinolin-5-amine | HCID 24820374 | — |
| 生成物 | Ethyl 1-(5-amino-6-chloroquinolin-2-yl)piperidine-4-carboxylate | HCID 69320002 | 71.8% |
反応手順
Prepared according to the method of example 30, using 2,6-dichloroquinolin-5-amine (Example 1(d)) (800 mg) and 4-piperidinecarboxylic acid, ethyl ester (1.8 g). Purification (SiO2, miethanol:dichloromethane 1:99 as eluant) gave the sub-title compound as a solid (900 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07408065B2 |
| 出典データセット | uspto-grants-2008_08 |
| ORD ID | ord-5e1c6f6da2c841d0bdbd637d4977daf3 |
| 出典メモ | uspto-grants-2008_08 |