Cyclohexanepropanoic acid → N-(2,6-Dichloro-5-quinolinyl)-cyclohexanepropanamide

HRID 2217894ノート

反応式

HRID 2217894 の反応式
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[C:8]([NH2:12])=[C:7]([Cl:13])[CH:6]=[CH:5][C:4]=2[N:3]=1.[CH:14]1([CH2:20][CH2:21][C:22](O)=[O:23])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>>[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:13])[C:8]=2[NH:12][C:22](=[O:23])[CH2:21][CH2:20][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[N:3]=1

参加物

3

反応物 2

HCID 69702Cyclohexanepropanoic acidHCID 248203742,6-Dichloroquinolin-5-amine

生成物 1

HCID 86012849N-(2,6-Dichloro-5-quinolinyl)-cyclohexanepropanamide

実験手順

Prepared according to the method of example 62(a), using 2,6-dichloroquinolin-5-amine (example 1(d)) (0.5 g) and cyclohexanepropionic acid (1.2 mL). The resulting precipitate was filtered and washed with acetone. The precipitate was further washed with water and then ether to give the sub-title compound as a solid (0.248 g)

後処理

  1. customPrepared
  2. filtrationThe resulting precipitate was filtered
  3. washwashed with acetone
  4. washThe precipitate was further washed with water

出典と根拠

ORDレコード
ord-a3b9ff56b53c43c195568aaeca3bbc90
出典データセット
uspto-grants-2008_08
特許番号
US07408065B2

反応ノート

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