Ethanol → 2,7-Dimethyl-1,2-dihydrophthalazin-1-one

HRID 221811

反応式

HRID 221811 の反応式
[CH:1]([C:3]1[CH:11]=[CH:10][C:9](OC)=[CH:8][C:4]=1[C:5]([OH:7])=O)=O.[CH3:14][NH:15][NH2:16].[CH2:17](O)C>>[CH3:17][C:9]1[CH:8]=[C:4]2[C:3]([CH:1]=[N:16][N:15]([CH3:14])[C:5]2=[O:7])=[CH:11][CH:10]=1

参加物

4

反応物 3

HCID 702EthanolHCID 6061MethylhydrazineHCID 71762052-Formyl-5-methoxybenzoic acid

生成物 1

HCID 670105172,7-Dimethyl-1,2-dihydrophthalazin-1-one

実験手順

A solution of 2-formyl-5-methoxy-benzoic acid (1.0 g, 6.10 mmol) and methyl hydrazine (0.481 mL, 1.5 eq.) in ethanol (15 mL) was stirred at 85° C. for 1.5 days. The solvent was removed and the solid was collected and washed with cold EtOH to give 7-methyl-2-methyl-2H-phthalazin-1-one (780 mg): MS m/z 191 (M+H).

後処理

  1. customThe solvent was removed
  2. customthe solid was collected
  3. washwashed with cold EtOH

出典と根拠

ORDレコード
ord-9d2282b2e82441e68e7a592a8ee34cbd
出典データセット
uspto-grants-2012_06
特許番号
US08207168B2

関連ノート

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