Acetic Anhydride → 3-(4-Nitrophenyl)pyridin-2(1H)-one

反応式

[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:11]=[N+:12]([O-])[CH:13]=[CH:14][CH:15]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2].C(OC(=O)C)(=[O:19])C>>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:11](=[O:19])[NH:12][CH:13]=[CH:14][CH:15]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

参加物

反応物 2

HCID 7918Acetic Anhydride

HCID 45557493-(4-Nitrophenyl)pyridine-1-oxide

生成物 1

HCID 541614103-(4-Nitrophenyl)pyridin-2(1H)-one

実験手順

3-(4-Nitrophenyl)pyridine-1-oxide (P2, 2.5 g, 11.6 mmol) was stirred at reflux in acetic anhydride (25 mL) for 18 hours, then allowed to cool. The reaction mixture was concentrated and concentrated hydrochloric acid (25 mL) was added. The solution was stirred at reflux for 4 hours, then allowed to cool. The reaction mixture was poured onto ice/water and filtration followed by drying under high vacuum afforded the title compound as a solid.

後処理

temperatureto cool
concentrationThe reaction mixture was concentrated
additionconcentrated hydrochloric acid (25 mL) was added
temperatureat reflux for 4 hours
temperatureto cool
additionThe reaction mixture was poured onto ice/water and filtration
customby drying under high vacuum

出典と根拠

ORDレコード: ord-b7d47c247a274c1ba22d9494a23fd9e0
出典データセット: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07410984B2

反応ノート

読み込み中…

参加物