Boron tribromide → 5-(4-Hydroxyphenyl)-2-methyl-2H-pyridazin-3-one

反応式

C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[N:13][N:12]([CH3:15])[C:11](=[O:16])[CH:10]=2)=[CH:5][CH:4]=1.B(Br)(Br)Br>>[OH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[N:13][N:12]([CH3:15])[C:11](=[O:16])[CH:10]=2)=[CH:5][CH:4]=1

参加物

反応物 2

HCID 25134Boron tribromide

HCID 569461985-(4-methoxy-phenyl)-2-methyl-2H-pyridazin-3-one

生成物 1

HCID 569461995-(4-Hydroxyphenyl)-2-methyl-2H-pyridazin-3-one

実験手順

5-(4-Hydroxyphenyl)-2-methyl-2H-pyridazin-3-one was prepared from 5-(4-methoxy-phenyl)-2-methyl-2H-pyridazin-3-one with BBr3 using the procedure described in Example 86 Step 2; Mp 296-8° C.; MS m/z 203 (M+H).

出典と根拠

ORDレコード: ord-74b38739f7a74239ab1b19a240fb3859
出典データセット: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08207168B2

反応ノート

読み込み中…