Hydrochloric Acid → 8-Cyclopropyl-4-ethoxyquinoline-2-carboxylic acid

HRID 2218308ノート

反応式

HRID 2218308 の反応式
[CH2:1]([O:3][C:4]1[C:13]2[C:8](=[C:9]([CH:14]3[CH2:16][CH2:15]3)[CH:10]=[CH:11][CH:12]=2)[N:7]=[C:6]([C:17]([O:19]C)=[O:18])[CH:5]=1)[CH3:2].Cl>C(Cl)(Cl)Cl.CO>[CH2:1]([O:3][C:4]1[C:13]2[C:8](=[C:9]([CH:14]3[CH2:16][CH2:15]3)[CH:10]=[CH:11][CH:12]=2)[N:7]=[C:6]([C:17]([OH:19])=[O:18])[CH:5]=1)[CH3:2]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 57440905Methyl 8-cyclopropyl-4-ethoxyquinoline-2-carboxylate

生成物 1

HCID 574408968-Cyclopropyl-4-ethoxyquinoline-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 21584188Chloroform methanol溶媒

実験手順

2.0 mL of 5N NaOHaq was added to a solution of 1.10 g of methyl 4-ethoxy-8-cyclopropylquinoline-2-carboxylate in 5 mL of CHCl3/MeOH (1:1) and the mixture was stirred at room temperature for 3 hr. After the addition of 3.0 mL of 5N HCl aq, the mixture was extracted by CHCl3. The organic layer was washed by satd. brine, dried over NaSO4, then concentrated to afford 4-ethoxy-8-cyclopropylquinoline-2-carboxylic acid as a colorless solid.

後処理

  1. extractionthe mixture was extracted by CHCl3
  2. washThe organic layer was washed by satd
  3. dry with materialbrine, dried over NaSO4
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-a18bcf50d9f3427d82b12df6f7607054
出典データセット
uspto-grants-2008_08
特許番号
US07410976B2

反応ノート

読み込み中…