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Water → 4,5-dichloro-2-methoxymethyl-2H-pyridazin-3-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 4,5-Dichloro-3-hydroxypyridazine | HCID 73247 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | Bromomethyl methyl ether | HCID 83093 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4,5-dichloro-2-methoxymethyl-2H-pyridazin-3-one | HCID 12351834 | 74.8% |
反応手順
To a stirred solution of 4,5-dichloropyridazin-6-one (5.00 g, 30.3 mmol) and N,N-diisopropylethylamine (7.92 mL, 45.5 mmol) in methylenechloride (50 mL) was added slowly, bromomethyl methyl ether (4.79 mL, 60.6 mmol) at room temperature (water-bath). The reaction was stirred for 22 h and was then concentrated. Purification by column chromatography (1% MeOH in CH2Cl2) gave 4.74 g (74.8%) of 4,5-dichloro-2-methoxymethyl-2H-pyridazin-3-one.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08207168B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-ae0fd16c91574504896206a7ea4213f6 |
| 出典メモ | uspto-grants-2012_06 |