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(4-Chloro-3-methoxyphenyl)boronic acid → HCID 68938275、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (4-Chloro-3-methoxyphenyl)boronic acid | HCID 23005377 | — |
| 反応物 | 5-bromomethylene-1-chloro-10,11dihydro-5H-dibenzo[a,d]cycloheptene | HCID 68891389 | — |
| 生成物 | HCID 68938275 | HCID 68938275 | 71% |
反応手順
Following procedures essentially as described in Example 219, below, and using 4-chloro-3-methoxyphenylboronic acid (160 mg,0.85 mmol) with 5-bromomethylene-1-chloro-10,11-dihydro-5H-dibenzo[a,d]cycloheptene (249 mg, 0.78 mmol) to give 440 mg crude product. Purify by chromatography to give 210 mg (71%) colorless oil. HPLC (ISO90-10M) shows 51% at t=7.62 min and 45% at t=9.86 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07411072B2 |
| 出典データセット | uspto-grants-2008_08 |
| ORD ID | ord-0ebd9318c8864a898f543e938ac47807 |
| 出典メモ | uspto-grants-2008_08 |