(4-Methanesulfonamidophenyl)boronic acid → N-[4-(1-Chloro-10,11-dihydro-dibenzo[a,d]cyclohepten-5ylidenemethyl)-phenyl]-methanesulfonamide

HRID 2218704

反応式

HRID 2218704 の反応式
Br[CH:2]=[C:3]1[C:9]2[CH:10]=[CH:11][CH:12]=[C:13]([Cl:14])[C:8]=2[CH2:7][CH2:6][C:5]2[CH:15]=[CH:16][CH:17]=[CH:18][C:4]1=2.[CH3:19][S:20]([NH:23][C:24]1[CH:29]=[CH:28][C:27](B(O)O)=[CH:26][CH:25]=1)(=[O:22])=[O:21]>>[Cl:14][C:13]1[C:8]2[CH2:7][CH2:6][C:5]3[CH:15]=[CH:16][CH:17]=[CH:18][C:4]=3[C:3](=[CH:2][C:27]3[CH:28]=[CH:29][C:24]([NH:23][S:20]([CH3:19])(=[O:22])=[O:21])=[CH:25][CH:26]=3)[C:9]=2[CH:10]=[CH:11][CH:12]=1

参加物

3

反応物 2

HCID 2773537(4-Methanesulfonamidophenyl)boronic acidHCID 688913895-bromomethylene-1-chloro-10,11dihydro-5H-dibenzo[a,d]cycloheptene

生成物 1

HCID 68939940N-[4-(1-Chloro-10,11-dihydro-dibenzo[a,d]cyclohepten-5ylidenemethyl)-phenyl]-methanesulfonamide

実験手順

Following procedures essentially as described in Example 219, below, and using 5-bromomethylene-1-chloro-10,11-dihydro-5H-dibenzo[a,d]cycloheptene (100 mg, 0.313 mmol) and 4-methanesulfonylaminophenylboronic acid (74 mg, 0.344 mmol), affords 55 mg (43%) of a mixture of geometric isomers of the title compound as a brown oil. MS (ES) 408 (M−H); HPLC shows 96% purity.

出典と根拠

ORDレコード
ord-a25755dac67a440dabdde3de210b8e93
出典データセット
uspto-grants-2008_08
特許番号
US07411072B2

関連ノート

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