Hydrochloric Acid → 3-Amino-1-(2-benzyloxy-ethyl)-5-(2,2,2-trifluoro-ethyl)-1,3,4,5-tetrahydro-benzo[b][1,4]diazepin-2-one hydrochloride
反応式
C(OC(=O)[NH:7][CH:8]1[C:14](=[O:15])[N:13]([CH2:16][CH2:17][O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:12]2[CH:26]=[CH:27][CH:28]=[CH:29][C:11]=2[N:10]([CH2:30][C:31]([F:34])([F:33])[F:32])[CH2:9]1)(C)(C)C.[ClH:36]>O1CCOCC1>[ClH:36].[NH2:7][CH:8]1[C:14](=[O:15])[N:13]([CH2:16][CH2:17][O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:12]2[CH:26]=[CH:27][CH:28]=[CH:29][C:11]=2[N:10]([CH2:30][C:31]([F:34])([F:33])[F:32])[CH2:9]1参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
In an analogous manner to that described in Example 1d), the treatment of the [1-(2-benzyloxy-ethyl)-2-oxo-5-(2,2,2-trifluoro-ethyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester with hydrochlorid acid (37%) in dioxane yielded quantitatively the title compound as a light yellow solid; MS (m/e): 394 (M+H)+.