Hydrochloric Acid → (4-Bromo-benzyloxy)-acetaldehyde
反応式
Cl.[Br:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][O:10][CH2:11][CH:12](OCC)[O:13]CC)=[CH:5][CH:4]=1>C(OCC)C.[Cl-].[Na+].O>[Br:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][O:10][CH2:11][CH:12]=[O:13])=[CH:7][CH:8]=1参加物
5
実験手順
5 N HCl (20 mL) is added to a stirred solution of 1-bromo 4-(2,2-diethoxy-ethoxymethyl)-benzene (1.86 g, 6.13 mmol) in diethyl ether (20 mL) at ambient temperature. The resultant two-layered mixture is stirred vigorously under nitrogen for 16 hours. Diethyl ether (30 mL) and brine (20 mL) are added to the mixture. The organic layer is separated, washed with half-saturated brine, dried, filter and concentrated into a ˜50 mL solution (35 mg/mL). 1H NMR (CDCl3): δ9.72 (s, 1H), 7.49 (d, J=7.49 Hz, 2H), 7.24 (d, J=7.9 Hz, 2H), 4.57 (s, 2H), 4.11 (s, 2H).
後処理
- customThe organic layer is separated
- washwashed with half-saturated brine
- customdried
- filtrationfilter
- concentrationconcentrated into a ˜50 mL solution (35 mg/mL)
出典と根拠
- ORDレコード
- ord-ddb3da2065374c6896e42bddf45ceebd
- 出典データセット
- uspto-grants-2008_08
- 特許番号
- US07414063B2
反応ノート
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