HCID 69215565、化合物 → HCID 9984224、化合物

HRID 2219289ノート

反応式

HRID 2219289 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:10][C@@:9]([CH3:16])([CH:11]([O:14][CH3:15])[O:12][CH3:13])[C@@H:8]3[O:17][C@@H:7]3[C:6]=2[CH:18]=1.[F:19][C:20]1[CH:25]=[CH:24][C:23]([NH:26][CH2:27][C:28]2[N:29]=[N:30][N:31]([CH3:33])[N:32]=2)=[CH:22][CH:21]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:10][C@@:9]([CH3:16])([CH:11]([O:14][CH3:15])[O:12][CH3:13])[C@H:8]([OH:17])[C@@H:7]([N:26]([C:23]3[CH:24]=[CH:25][C:20]([F:19])=[CH:21][CH:22]=3)[CH2:27][C:28]3[N:29]=[N:30][N:31]([CH3:33])[N:32]=3)[C:6]=2[CH:18]=1

参加物

3

反応物 2

HCID 69215565HCID 69215565、化合物HCID 86603164HCID 86603164、化合物

生成物 1

HCID 9984224HCID 9984224、化合物収率 53.2%

実験手順

The same procedure as step 3 of example 1 was accomplished, except for using (2R,3R,4R)-6-bromo-2-methyl-2-dimethoxymethyl-3,4-epoxy-3,4-dihydro-2H-1-benzopyran (198 mg, 0.63 mmol) and N-(4-fluorophenyl)-N-(2-methyl-2H-tetrazol-5-ylmethyl)amine (130 mg, 0.63 mmol). The crude product was purified by silica gel column chromatography (developing solvent-n-hexane:ethyl acetate=4:1), to give desired compound (175 mg, yield: 53%).

後処理

  1. customThe crude product was purified by silica gel column chromatography (developing solvent-n-hexane:ethyl acetate=4:1)

出典と根拠

ORDレコード
ord-937bf8ff9a674f7e9a78bfe5741d4251
出典データセット
uspto-grants-2008_08
特許番号
US07414068B2

反応ノート

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