(3-Chlorophenyl)boronic acid → HCID 23725324、化合物

反応式

[NH:1]1[CH:5]=[C:4]([C:6]2[C:7]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)=[N:8][O:9][C:10]=2[CH3:11])[N:3]=[CH:2]1.[Cl:19][C:20]1[CH:21]=[C:22](B(O)O)[CH:23]=[CH:24][CH:25]=1>>[Cl:19][C:20]1[CH:25]=[C:24]([N:1]2[CH:5]=[C:4]([C:6]3[C:7]([C:12]4[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=4)=[N:8][O:9][C:10]=3[CH3:11])[N:3]=[CH:2]2)[CH:23]=[CH:22][CH:21]=1

参加物

反応物 2

HCID 2734323(3-Chlorophenyl)boronic acid

HCID 178434995HCID 178434995、化合物

生成物 1

HCID 23725324HCID 23725324、化合物収率 4%

実験手順

As described for Example 3, 4-(1H-imidazol-4-yl)-5-methyl-3-(4-fluorophenyl)-isoxazole (73 mg, 0.3 mmol) was converted, using 3-chlorophenylboronic acid instead of 4-fluorophenylboronic acid, to the title compound (5 mg, 4%) which was obtained as an off-white solid. MS: m/e=354.6 [M+H]+.

出典と根拠

ORDレコード: ord-1ddda5d85ddb48ee8505b589a76267fe
出典データセット: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07414061B2

反応ノート

読み込み中…