Water → HCID 67420992、化合物

HRID 2219419ノート

反応式

HRID 2219419 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]3[N:14]=[CH:15][NH:16][CH:17]=3)=[C:11]([CH2:18][O:19][CH3:20])[O:10][N:9]=2)=[CH:4][CH:3]=1.F[C:22]1[CH:27]=[CH:26][C:25]([C:28](=[O:30])[CH3:29])=[CH:24][CH:23]=1.C(=O)([O-])[O-].[K+].[K+].O>CN(C=O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]3[N:14]=[CH:15][N:16]([C:22]4[CH:27]=[CH:26][C:25]([C:28](=[O:30])[CH3:29])=[CH:24][CH:23]=4)[CH:17]=3)=[C:11]([CH2:18][O:19][CH3:20])[O:10][N:9]=2)=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 962WaterHCID 98284'-FluoroacetophenoneHCID 11430Potassium CarbonateHCID 1784947533-(4-fluoro-phenyl)-4-(1H-imidazol-4-yl)-5-methoxymethyl-isoxazole

生成物 1

HCID 67420992HCID 67420992、化合物収率 84.3%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
120 °C

実験手順

A mixture of 3-(4-fluoro-phenyl)-4-(1H-imidazol-4-yl)-5-methoxymethyl-isoxazole (273 mg, 1.0 mmol), 1-(4-fluorophenyl)-ethanone (212 mg, 1.5 mmol), and potassium carbonate (276 mg, 2.0 mmol) in DMF (4 mL) was stirred at 120° C. for 16 h. After cooling to room temperature, the resulting solution was poured into cold water and stirred for 15 min. The precipitate was collected by filtration, washed with water, hexane, and dried to afford the title compound (330 mg, 79%) which was obtained as light brown solid. MS: m/e=392.5[M+H]+.

後処理

  1. temperatureAfter cooling to room temperature
  2. stirringstirred for 15 min
  3. filtrationThe precipitate was collected by filtration
  4. washwashed with water, hexane
  5. customdried

出典と根拠

ORDレコード
ord-8dafa5003d0c41fd810befcf5fbfba9d
出典データセット
uspto-grants-2008_08
特許番号
US07414061B2

反応ノート

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