3-Bromo-4-methylpyridine → 6-Methyl-3-(4-methyl-pyridin-3-ylamino)-pyridine-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide

HRID 2219499ノート

反応式

HRID 2219499 の反応式
[CH3:1][C:2]1[N:3]=[C:4]([NH:7][C:8]([C:10]2[C:15]([NH:16][C:17]3[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=3)=[CH:14][CH:13]=[C:12]([CH3:23])[N:11]=2)=[O:9])[S:5][CH:6]=1.Br[C:25]1C=NC=CC=1C>>[CH3:1][C:2]1[N:3]=[C:4]([NH:7][C:8]([C:10]2[C:15]([NH:16][C:17]3[CH:18]=[N:19][CH:20]=[CH:21][C:22]=3[CH3:25])=[CH:14][CH:13]=[C:12]([CH3:23])[N:11]=2)=[O:9])[S:5][CH:6]=1

参加物

3

反応物 2

HCID 8176303-Bromo-4-methylpyridineHCID 115371406-Methyl-3-(pyridin-3-ylamino)-pyridine-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide

生成物 1

HCID 250969076-Methyl-3-(4-methyl-pyridin-3-ylamino)-pyridine-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide

実験手順

The title compound, was prepared from 3-Amino-6-methyl-pyridine-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide (example 14) in accordance with the general method of example 20 using 3-Bromo-4-methylpyridine instead of 3-Bromo-4-methylpyridine to yield the final compound as an off-white solid, MS (ISP): m/e=340.3 (M+H+).

出典と根拠

ORDレコード
ord-682403a6fb8648a39e4c51f06b3a538d
出典データセット
uspto-grants-2008_08
特許番号
US07414060B2

反応ノート

読み込み中…