2-Methyl-1,3-thiazol-4-amine → 6-Methyl-3-(2-methyl-2H-pyrazol-3-ylamino)-pyridine-2-carboxylic acid (2-methyl-thiazol-4-yl)-amide
反応式
C(O[C:4]([C:6]1[C:11]([NH:12][C:13]2[N:14]([CH3:18])[N:15]=[CH:16][CH:17]=2)=[CH:10][CH:9]=[C:8]([CH3:19])[N:7]=1)=[O:5])C.[NH2:20][C:21]1[N:22]=[C:23]([CH3:26])[S:24][CH:25]=1>>[CH3:26][C:23]1[S:24][CH:25]=[C:21]([NH:20][C:4]([C:6]2[C:11]([NH:12][C:13]3[N:14]([CH3:18])[N:15]=[CH:16][CH:17]=3)=[CH:10][CH:9]=[C:8]([CH3:19])[N:7]=2)=[O:5])[N:22]=1参加物
3
実験手順
The title compound, was prepared from 6-Methyl-3-(2-methyl-2H-pyrazol-3-ylamino)-pyridine-2-carboxylic acid ethyl ester in accordance with the general method of example 75, step 2 using 4-Amino-2-methylthiazole instead of 3-Amino-1-methyl-pyrazole to yield the final compound as a light brown solid, MS (ISP): m/e=329.1 (M+H+).
出典と根拠
- ORDレコード
- ord-d1c072b7d00d4a21bdd9df8cdb167405
- 出典データセット
- uspto-grants-2008_08