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Diisopropylethylamine → HCID 178517175、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | Methyl phenylglyoxalate | HCID 84835 | — |
| 反応物 | 5-Chloropyrazine-2,3-diamine | HCID 70700882 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | HCID 178517175 | HCID 178517175 | — |
反応手順
A mixture of 6-chloro-2,3-pyrazinediamine (3-1) (15.3 g, 107 mmol), DIPEA (37.2 mL, 213 mmol), and methyl oxo(phenyl)acetate (26.2 g, 160 mmol) in THF (300 mL) was stirred at room temperature for 2 days. The solvent was concentrated under reduced pressure, and EtOAc was added. The resulting solid was collected by filtration to give 6-chloro-3-phenylpyrido[2,3-b]pyrazin-2-ol (3-2) as yellow powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08207169B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-808cafb884a848d09ecaa0b7b9a9ce3c |
| 出典メモ | uspto-grants-2012_06 |