(R)-(4-azido-3,4-dihydro-2H-chromen-7-yl)methanol → (R)-4-azido-3,4-dihydro-2H-chromene-7-carbaldehyde
反応式
[N:1]([C@H:4]1[C:13]2[C:8](=[CH:9][C:10]([CH2:14][OH:15])=[CH:11][CH:12]=2)[O:7][CH2:6][CH2:5]1)=[N+:2]=[N-:3]>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[N:1]([C@H:4]1[C:13]2[C:8](=[CH:9][C:10]([CH:14]=[O:15])=[CH:11][CH:12]=2)[O:7][CH2:6][CH2:5]1)=[N+:2]=[N-:3]参加物
4
実験手順
To a stirred solution of (R)-(4-azido-3,4-dihydro-2H-chromen-7-yl)methanol (3.293 g, 16.05 mmol) in 50 mL DCM was added manganese dioxide (160.3 mmol, 10.0 eq). The reaction mixture was allowed to stir overnight. A second portion of manganese dioxide (57.84 mmol, 3.5 eq) was added and stirred an additional 4 h. The reaction mixture was filtered and concentrated to yield the aldehyde.
後処理
- stirringstirred an additional 4 h
- filtrationThe reaction mixture was filtered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-08fd58960f474befa20f83b305fa3f18
- 出典データセット
- uspto-grants-2008_08
- 特許番号
- US07414134B2
反応ノート
読み込み中…