Acetic Anhydride → 4-Phenylmorpholine-2,6-dione

HRID 2220017ノート

反応式

HRID 2220017 の反応式
[C:1]1([N:7]([CH2:12][C:13]([OH:15])=[O:14])[CH2:8][C:9]([OH:11])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(OC(=O)C)(=O)C.CCCCCC>C1(C)C=CC=CC=1>[C:1]1([N:7]2[CH2:8][C:9](=[O:11])[O:15][C:13](=[O:14])[CH2:12]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

5

反応物 3

HCID 7918Acetic AnhydrideHCID 8058HexaneHCID 136915N-Phenyliminodiacetic acid

生成物 1

HCID 5632194-Phenylmorpholine-2,6-dione収率 90.6%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

In a 2-liter eggplant type flask, 62.8 g of N-phenyl-iminodiacetic acid was charged and dissolved in 500 mL of toluene under a nitrogen gas stream, to which was then added 32.0 g of acetic anhydride. The mixture was refluxed under heating and stirred. One hour thereafter, the reaction mixture was cooled to room temperature, to which was then 3 L of hexane with stirring to undergo deposition. A reaction product was filtered to obtain 52.0 g of N-phenyliminodiacetic anhydride.

後処理

  1. temperatureThe mixture was refluxed
  2. temperatureunder heating
  3. filtrationA reaction product was filtered

出典と根拠

ORDレコード
ord-91ead07cd5834ae3bfc34813d1072c0c
出典データセット
uspto-grants-2008_08
特許番号
US07416835B2

反応ノート

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