Hydrochloric Acid → 1-Butyl-4-(3-trifluoromethyl-phenyl)piperidine

反応式

[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]([CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1.[CH2:17](Br)[CH2:18][CH2:19][CH3:20].Cl>>[CH2:17]([N:12]1[CH2:11][CH2:10][CH:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:15])[F:16])[CH:4]=2)[CH2:14][CH2:13]1)[CH2:18][CH2:19][CH3:20]

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 8002Butyl bromide

HCID 117363404-(3-(Trifluoromethyl)Phenyl)Piperidine

生成物 1

HCID 223978491-Butyl-4-(3-trifluoromethyl-phenyl)piperidine

実験手順

Beginning with 4-(3-Trifluoromethyl-phenyl)piperidine and n-Bu-Br: m.p. 222° C. (HCl), MS m/z (rel. intensity, 70 eV) 285 (M+, 3), 243 (12), 242 (bp), 70 (51), 56 (17).

出典と根拠

ORDレコード: ord-9aee2812d92446b294bf5e7a7b4d2702
出典データセット: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07417043B2

反応ノート

読み込み中…