Ammonium Hydroxide → 4-Bromo-2-fluorobenzenesulphonamide
反応式
[OH-].[NH4+:2].[Br:3][C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[C:6]([F:14])[CH:5]=1>ClCCl>[Br:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH2:2])(=[O:12])=[O:11])=[C:6]([F:14])[CH:5]=1参加物
4
実験手順
To a ammonium hydroxide (28%, 80 ml) was added a solution of 4-bromo-2-fluorobenzenesulfonyl chloride (10 g) in dichloromethane (80 ml) dropwise for 1 hour at approximately 0° C. The reaction mixture was stirred vigorously for an additional 2 hours at the same temperature. The phases were separated. The aqueous phase was washed with dichloromethane. The combined organic extracts were washed with brine, dried over sodium sulfate and evaporated to give 4-bromo-2-fluorobenzenesulfonamide (8.0 g).
後処理
- customThe phases were separated
- washThe aqueous phase was washed with dichloromethane
- washThe combined organic extracts were washed with brine
- dry with materialdried over sodium sulfate
- customevaporated
出典と根拠
- ORDレコード
- ord-811634a4ef184929b379d0bad9fb230e
- 出典データセット
- uspto-grants-2008_08
- 特許番号
- US07417060B2
反応ノート
読み込み中…