(R)-2-(4-Nitrophenyl)oxirane → (1R)-2-[[2-(4-iodophenoxy)ethyl]amino]-1-(4-nitrophenyl)ethanol

HRID 2220392ノート

反応式

HRID 2220392 の反応式
[I:1][C:2]1[CH:11]=[CH:10][C:5]([O:6][CH2:7][CH2:8][NH2:9])=[CH:4][CH:3]=1.C/C(/O[Si](C)(C)C)=N\[Si](C)(C)C.[N+:24]([C:27]1[CH:32]=[CH:31][C:30]([C@@H:33]2[CH2:35][O:34]2)=[CH:29][CH:28]=1)([O-:26])=[O:25]>CS(C)=O>[I:1][C:2]1[CH:11]=[CH:10][C:5]([O:6][CH2:7][CH2:8][NH:9][CH2:35][C@@H:33]([C:30]2[CH:29]=[CH:28][C:27]([N+:24]([O-:26])=[O:25])=[CH:32][CH:31]=2)[OH:34])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 1237170(R)-2-(4-Nitrophenyl)oxiraneHCID 6913588N,O-bis(trimethylsilyl)acetamideHCID 185433782-(4-Iodo-phenoxy)-ethylamine

生成物 1

HCID 69103738(1R)-2-[[2-(4-iodophenoxy)ethyl]amino]-1-(4-nitrophenyl)ethanol収率 90.3%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒2 回

実験手順

To a solution of [2-(4-iodophenoxy)ethyl]amine (6.14 g) in dimethyl sulfoxide (50 ml) was added N,O-bis(trimethylsilyl)acetamide (2.88 ml) and the mixture was stirred for 1 hour. To the mixture was added a solution of (2R)-2-(4-nitrophenyl)oxirane (3.21 g) in dimethyl sulfoxide (10 ml) and the mixture was stirred for 37 hours. After cooling to room temperature, the mixture was quenched by the addition of 5% acetic acid/water (120 ml) and stirred for 30 minutes. The mixture was basified with 1N sodium hydroxide and extracted with ethyl acetate (120 ml). The extract was washed with water (120 ml×2) and brine (120 ml), and dried over magnesium sulfate. Filtration followed by evaporation gave (1R)-2-[[2-(4-iodophenoxy)ethyl]amino]-1-(4-nitrophenyl)ethanol (7.52 g) as a brown solid. The compound was used in the next step without further purification.

後処理

  1. stirringthe mixture was stirred for 37 hours
  2. customthe mixture was quenched by the addition of 5% acetic acid/water (120 ml)
  3. stirringstirred for 30 minutes
  4. extractionextracted with ethyl acetate (120 ml)
  5. washThe extract was washed with water (120 ml×2) and brine (120 ml)
  6. dry with materialdried over magnesium sulfate
  7. filtrationFiltration
  8. customfollowed by evaporation

出典と根拠

ORDレコード
ord-d3108714b2e9453badc21e45f82899b2
出典データセット
uspto-grants-2008_08
特許番号
US07417060B2

反応ノート

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