Ethyl 4-benzyloxy-2-ethylbenzoate → Ethyl 2-ethyl-4-hydroxybenzoate
反応式
C([O:8][C:9]1[CH:19]=[CH:18][C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:11]([CH2:20][CH3:21])[CH:10]=1)C1C=CC=CC=1>C(O)C.[C].[Pd]>[CH2:20]([C:11]1[CH:10]=[C:9]([OH:8])[CH:19]=[CH:18][C:12]=1[C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH3:21]参加物
4
実験手順
To a solution of ethyl 4-benzyloxy-2-ethylbenzoate (0.633 g) in ethanol (6.2 mL) was added 10% palladium-carbon (0.227 g), and the mixture was stirred at room temperature for 1.2 hrs under an atmosphere of hydrogen. The catalyst was removed by filtration, and the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (eluent: ethyl acetate/n-hexane=1/8) to afford the title compound (0.224 g).
後処理
- customThe catalyst was removed by filtration
- concentrationthe filtrate was concentrated in vacuo
- customThe residue was purified by silica gel column chromatography (eluent: ethyl acetate/n-hexane=1/8)
出典と根拠
- ORDレコード
- ord-af7dadd204e8468596d89f9f1a6e13ac
- 出典データセット
- uspto-grants-2008_08
- 特許番号
- US07417169B2
反応ノート
読み込み中…