HCID 69201908、化合物 → 4'-{2-[(1S,2R)-2-Hydroxy-2-(4-hydroxy-3-methanesulfonylaminophenyl)-1-methylethylamino]ethoxy}-3',5'-dimethylbiphenyl-4-carboxylic acid

HRID 2220657ノート

反応式

HRID 2220657 の反応式
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C@@H:15]([OH:46])[C@@H:16]([NH:18][CH2:19][CH2:20][O:21][C:22]2[C:27]([CH3:28])=[CH:26][C:25]([C:29]3[CH:34]=[CH:33][C:32]([C:35]([O:37]CC4C=CC=CC=4)=[O:36])=[CH:31][CH:30]=3)=[CH:24][C:23]=2[CH3:45])[CH3:17])=[CH:11][C:10]=1[NH:47][S:48]([CH3:51])(=[O:50])=[O:49])C1C=CC=CC=1>CN(C)C=O.[C].[Pd]>[OH:46][C@H:15]([C:12]1[CH:13]=[CH:14][C:9]([OH:8])=[C:10]([NH:47][S:48]([CH3:51])(=[O:50])=[O:49])[CH:11]=1)[C@@H:16]([NH:18][CH2:19][CH2:20][O:21][C:22]1[C:27]([CH3:28])=[CH:26][C:25]([C:29]2[CH:34]=[CH:33][C:32]([C:35]([OH:37])=[O:36])=[CH:31][CH:30]=2)=[CH:24][C:23]=1[CH3:45])[CH3:17]

参加物

4

反応物 1

HCID 69201908HCID 69201908、化合物

生成物 1

HCID 692010834'-{2-[(1S,2R)-2-Hydroxy-2-(4-hydroxy-3-methanesulfonylaminophenyl)-1-methylethylamino]ethoxy}-3',5'-dimethylbiphenyl-4-carboxylic acid収率 65.2%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 6228Dimethylformamide溶媒

実験手順

To a solution of benzyl 4′-{2-[(1S,2R)-2-(4-benzyloxy-3-methanesulfonylaminophenyl)-2-hydroxy-1-methylethylamino]ethoxy}-3′,5′-dimethylbiphenyl-4-carboxylate (0.074 g) in N,N-dimethylformamide (4 mL) was added 10% palladium-carbon (0.05 g), and the mixture was stirred at room temperature for 1.5 hrs under an atmosphere of hydrogen. The catalyst was removed by filtration, and the solvent was evaporated under reduced pressure. Methylene chloride was added to the residue, and the resulting precipitated materials were collected by filtration. The crude product was purified by ODS column chromatography (eluent: acetonitrile/water=1/1) to afford the title compound (0.036 g).

後処理

  1. customThe catalyst was removed by filtration
  2. customthe solvent was evaporated under reduced pressure
  3. additionMethylene chloride was added to the residue
  4. customthe resulting precipitated materials
  5. filtrationwere collected by filtration
  6. customThe crude product was purified by ODS column chromatography (eluent: acetonitrile/water=1/1)

出典と根拠

ORDレコード
ord-f9ab299eb7f74fb3b504ee48d301918b
出典データセット
uspto-grants-2008_08
特許番号
US07417169B2

反応ノート

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