HCID 69204095、化合物 → HCID 69201523、化合物
反応式
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C@@H:15]([OH:36])[CH2:16][NH:17][CH2:18][CH2:19][O:20][C:21]2[CH:26]=[CH:25][C:24]([C:27]3[CH:32]=[CH:31][C:30]([C:33]([OH:35])=[O:34])=[CH:29][CH:28]=3)=[CH:23][CH:22]=2)=[CH:11][C:10]=1[NH:37][S:38]([CH3:41])(=[O:40])=[O:39])C1C=CC=CC=1>CN(C)C(=O)C.[C].[Pd]>[OH:36][C@H:15]([C:12]1[CH:13]=[CH:14][C:9]([OH:8])=[C:10]([NH:37][S:38]([CH3:41])(=[O:40])=[O:39])[CH:11]=1)[CH2:16][NH:17][CH2:18][CH2:19][O:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]2[CH:28]=[CH:29][C:30]([C:33]([OH:35])=[O:34])=[CH:31][CH:32]=2)=[CH:23][CH:22]=1参加物
4
実験手順
A suspension of the crude 4′-{2-[(R)-2-(4-benzyloxy-3-methanesulfonylaminophenyl)-2-hydroxyethylamino]ethoxy}biphenyl-4-carboxylic acid and 10% palladium-carbon (0.03 g) in N,N-dimethylacetamide (5 mL) was stirred at room temperature for 2 hrs under an atmosphere of hydrogen. The catalyst was removed by filtration, and the solvent was evaporated under reduced pressure. The residue was triturated in methylene chloride, and then dissolved by addition of acetonitrile (5 mL) and water (5 mL) The insoluble materials were removed by filtration, and the solvent was evaporated under reduced pressure to afford the title compound (0.045 g).