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Methanethiol → 1-(1-Methyl-4-pyrazolylmethyl)2-(nitromethylene)tetrahydropyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanethiol | HCID 878 | — |
| 反応物 | 1,1-Bis(methylthio)-2-nitroethylene | HCID 83623 | — |
| 反応物 | N-(1-methyl-4-pyrazolylmethyl)trimethylenediamine | HCID 14207161 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-(1-Methyl-4-pyrazolylmethyl)2-(nitromethylene)tetrahydropyrimidine | HCID 70249087 | 70.1% |
反応手順
A mixture of 16.8 g of N-(1-methyl-4-pyrazolylmethyl)-trimethylenediamine, 16.5 g of 1-nitro-2,2-bis(methylthio)ethylene and 200 ml of ethanol was heated under reflux until the generation of methylmercaptan ceased. The mixture was cooled, and the precipitated crystals were collected by filtration. Washing with methanol gave 16.6 g of the desired 1-(1-methyl-4-pyrazolylmethyl)2-(nitromethylene)tetrahydropyrimidine as pale yellow crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05428032 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-2bc2df6bc147415a9b2cca3c9d532670 |
| 出典メモ | uspto-grants-1995_06 |