Hydrogen Peroxide → 6-Bromo-3-(dimethylamino)-1,2,4-triazin-5(2H)-one
反応式
[OH:1]O.[Br:3][C:4]1[N:9]=[N:8][C:7]([N:10]([CH3:12])[CH3:11])=[N:6][CH:5]=1>C(O)(=O)C>[Br:3][C:4]1[C:5](=[O:1])[NH:6][C:7]([N:10]([CH3:12])[CH3:11])=[N:8][N:9]=1参加物
4
反応条件
- 温度
- 25 °C
実験手順
Hydrogen peroxide (27% strength solution in water, 0.53 ml, 4.56 mmol) was added at 5° C. to a solution of 6-bromo-3-dimethylamino-1,2,4-triazine (IX) (J. Org. Chem. 43 (1978) 2514) (500 mg, 2.46 mmol) in glacial acetic acid (4 ml), and the reaction mixture was stirred at 25° C. for 12 hours. The resulting precipitate was collected, washed with water, dried in the air and recrystallized from ethanol. The ketone (X) (368 mg, 68%) was obtained as white crystals of melting point 261-262° C. (ethanol).
後処理
- customThe resulting precipitate was collected
- washwashed with water
- customdried in the air
- customrecrystallized from ethanol
出典と根拠
- ORDレコード
- ord-c0e4f54145a642808d55d1e36d48c74b
- 出典データセット
- uspto-grants-2008_05
- 特許番号
- US07368437B1
反応ノート
読み込み中…