2-Pyrrolidone → HCID 69215404、化合物

HRID 2221366ノート

反応式

HRID 2221366 の反応式
Cl[CH2:2][Si:3]([O:6][CH3:7])([CH3:5])[CH3:4].[O-:8][C:9]#[N:10].[K+].[NH:12]1[CH2:16][CH2:15][CH2:14][C:13]1=[O:17]>CN(C=O)C>[CH3:7][O:6][Si:3]([CH2:2][NH:10][C:9]([N:12]1[CH2:16][CH2:15][CH2:14][C:13]1=[O:17])=[O:8])([CH3:5])[CH3:4]

参加物

5

反応物 3

HCID 120252-PyrrolidoneHCID 560623(Chloromethyl)methoxydimethylsilaneHCID 11378442Potassium cyanate

生成物 1

HCID 69215404HCID 69215404、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
130 °C

実験手順

A mixture of 69.3 g of (chloromethyl)methoxydimethyl-silane, 40.6 g of potassium cyanate and 42.6 g of 2-pyrrolidinone in 150 ml of anhydrous DMF was heated at 130° C. with stirring for 5 h. The solvent was then removed under reduced pressure. This gave N-[(methoxydimethylsilyl)methyl]-2-oxo-1-pyrrolidinecarboxamide in quantitative yield with a purity of >90% (analysis by 1H NMR, see Example 2a).

後処理

  1. customThe solvent was then removed under reduced pressure

出典と根拠

ORDレコード
ord-40873512c0c041d4b579c07ef7f793aa
出典データセット
uspto-grants-2008_05
特許番号
US07368586B2

反応ノート

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