Acetic Anhydride → N-(2-oxooxolan-3-yl)acetamide

HRID 2221381

反応式

HRID 2221381 の反応式
[NH2:1][C@H:2]([C:6]([OH:8])=[O:7])[CH2:3][CH2:4]O.CN(C1C=CC=CN=1)C.[C:18](OC(=O)C)(=[O:20])[CH3:19]>>[C:18]([NH:1][CH:2]1[CH2:3][CH2:4][O:7][C:6]1=[O:8])(=[O:20])[CH3:19]

参加物

4

反応物 3

HCID 7918Acetic AnhydrideHCID 12647L-HomoserineHCID 218852-Dimethylaminopyridine

生成物 1

HCID 325257N-(2-oxooxolan-3-yl)acetamide収率 60%

反応条件

温度
60 °C

実験手順

L-Homoserine (2 mol) was suspended in 900 ml of acetic anhydride and admixed with a spatula tip full of dimethylaminopyridine (DMAP). It was slowly heated to 60° C. After approximately 1 hour, the temperature rapidly increased to 100° C. Subsequently the reaction mixture was stirred at 80° C. for 90 minutes and concentrated to dryness under vacuum. The resultant yellow oil was taken up in isopropanol (600 ml) and allowed to stand overnight at 0° C. The resultant crystals were filtered off, washed with cold isopropanol and dried under vacuum. The yield was 60% N-acetyl-2-amino-4-butyrolactone isolated, the purity 99% (according to HPLC).

後処理

  1. temperaturethe temperature rapidly increased to 100° C
  2. concentrationconcentrated to dryness under vacuum
  3. waitto stand overnight at 0° C
  4. filtrationThe resultant crystals were filtered off
  5. washwashed with cold isopropanol
  6. customdried under vacuum

出典と根拠

ORDレコード
ord-352eca809da94d408397cf48d8d36b0f
出典データセット
uspto-grants-2008_05
特許番号
US07368600B2

関連ノート

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