1,1-Bis(methylthio)-2-nitroethylene → 1-(2-Chloro-5-pyridylmethyl)4-methyl-2-(nitromethylene)imidazolidine

HRID 22215

反応式

HRID 22215 の反応式
[NH2:1][CH:2]([CH3:13])[CH2:3][NH:4][CH2:5][C:6]1[CH:7]=[CH:8][C:9]([Cl:12])=[N:10][CH:11]=1.[N+:14]([CH:17]=[C:18](SC)SC)([O-:16])=[O:15]>CO>[Cl:12][C:9]1[CH:8]=[CH:7][C:6]([CH2:5][N:4]2[CH2:3][CH:2]([CH3:13])[NH:1][C:18]2=[CH:17][N+:14]([O-:16])=[O:15])=[CH:11][N:10]=1

参加物

4

反応物 2

HCID 836231,1-Bis(methylthio)-2-nitroethyleneHCID 139209182-Amino-1-(2-chloro-5-pyridylmethylamino)propane

生成物 1

HCID 867421431-(2-Chloro-5-pyridylmethyl)4-methyl-2-(nitromethylene)imidazolidine収率 73%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 2 g of 2-amino-1-(2-chloro-5-pyridylmethylamino)propane, 1.6 g of 1-nitro-2,2-bis(methylthio)ethylene and 20 ml of methanol was refluxed for hours with stirring. A crystaline product was precipitated after standing at room temperature. The product was filtered with suction, washed with methanol and then dried in vacuum. 1.9 g of 1-(2-chloro-5-pyridylmethyl)-4-methyl-2-(nitromethylene)imidazolidine was obtained in form of light yellow crystals.

後処理

  1. temperaturewas refluxed for hours
  2. customA crystaline product was precipitated
  3. customafter standing at room temperature
  4. filtrationThe product was filtered with suction
  5. washwashed with methanol
  6. customdried in vacuum

出典と根拠

ORDレコード
ord-1bd1791614cd400c8e7f793356fce6e3
出典データセット
uspto-grants-1995_06
特許番号
US05428032

関連ノート

読み込み中…