Triethyl phosphite → Diethyl [(2-ethyl-5-methyl-1,3-thiazol-4-yl)methyl]phosphonate
反応式
Cl[CH2:2][C:3]1[N:4]=[C:5]([CH2:9][CH3:10])[S:6][C:7]=1[CH3:8].[P:11]([O:18]CC)([O:15][CH2:16][CH3:17])[O:12][CH2:13][CH3:14]>>[CH2:9]([C:5]1[S:6][C:7]([CH3:8])=[C:3]([CH2:2][P:11](=[O:18])([O:15][CH2:16][CH3:17])[O:12][CH2:13][CH3:14])[N:4]=1)[CH3:10]参加物
3
反応条件
- 温度
- 160 °C
実験手順
A mixture of 4-chloromethyl-2-ethyl-5-methyl-1,3-thiazole (3.2 g) and triethyl phosphite (6.7 g) was stirred at 160° C. for 16 hrs. Excess triethyl phosphite was evaporated under reduced pressure. The residue was subjected to silica gel column chromatography and eluted with ethyl acetate-hexane (1:2-1:1, v/v) to give diethyl [(2-ethyl-5-methyl-1,3-thiazol-4-yl)methyl]phosphonate as a colorless oil (4.9 g, yield 97%).
後処理
- customExcess triethyl phosphite was evaporated under reduced pressure
- washeluted with ethyl acetate-hexane (1:2-1:1
出典と根拠
- ORDレコード
- ord-1265314925eb4185a428288afc803302
- 出典データセット
- uspto-grants-2008_05
- 特許番号
- US07368578B2
反応ノート
読み込み中…