Hydrochloric Acid → HCID 178435093、化合物

HRID 2221712ノート

反応式

HRID 2221712 の反応式
COC[O:4][C:5]1[C:9](/[CH:10]=[CH:11]/[C:12]2[N:13]=[C:14]([N:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[S:15][C:16]=2[CH3:17])=[CH:8][N:7]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[N:6]=1.[ClH:30]>CO>[ClH:30].[CH3:17][C:16]1[S:15][C:14]([N:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)=[N:13][C:12]=1/[CH:11]=[CH:10]/[C:9]1[C:5]([OH:4])=[N:6][N:7]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:8]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 230765591-(4-{(E)-2-[3-(methoxymethoxy)-1-phenyl-1H-pyrazol-4-yl]ethenyl}-5-methyl-1,3-thiazol-2-yl)piperidine

生成物 1

HCID 178435093HCID 178435093、化合物収率 81%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
50 °C

実験手順

To a solution of 1-(4-{(E)-2-[3-(methoxymethoxy)-1-phenyl-1H-pyrazol-4-yl]ethenyl}-5-methyl-1,3-thiazol-2-yl)piperidine (0.61 g) in methanol (30 mL) was added concentrated hydrochloric acid (0.3 mL) at room temperature, and the mixture was stirred at 50° C. for 1 hr. The reaction mixture was evaporated under reduced pressure, and the residue was washed with ethyl acetate-methanol to give 4-({E}-2-[5-methyl-2-(piperidin-1-yl)-1,3-thiazol-4-yl]ethenyl)-1-phenyl-1H-pyrazol-3-ol.hydrochloride (0.49 g, yield 81%) as yellow prism crystals. melting point: 224-226° C.

後処理

  1. customThe reaction mixture was evaporated under reduced pressure
  2. washthe residue was washed with ethyl acetate-methanol

出典と根拠

ORDレコード
ord-4f8848b50c6844acaf1af358f37c858f
出典データセット
uspto-grants-2008_05
特許番号
US07368578B2

反応ノート

読み込み中…