Bromopyruvic Acid → 2-[[4-(Trifluoromethoxy)phenyl]amino]-4-thiazolecarboxylic acid
反応式
[F:1][C:2]([F:15])([F:14])[O:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([NH2:13])=[S:12])=[CH:6][CH:5]=1.Br[CH2:17][C:18](=O)[C:19]([OH:21])=[O:20]>C(O)C>[F:15][C:2]([F:14])([F:1])[O:3][C:4]1[CH:5]=[CH:6][C:7]([NH:10][C:11]2[S:12][CH:17]=[C:18]([C:19]([OH:21])=[O:20])[N:13]=2)=[CH:8][CH:9]=1参加物
4
反応条件
- 温度
- 60 °C
実験手順
A mixture of 12.9 g (54.6 mmol) [4-(trifluoromethoxy)phenyl]-thiourea, and 9.3 g (55.7 mmol) bromopyruvic acid in 70 ml ethanol was heated to 60° C. for 1 h. The precipitate was filtered off and washed with small portions of cold ethanol to yield after drying 8.9 g (53%) of the title compound as crystalline solid.
後処理
- filtrationThe precipitate was filtered off
- washwashed with small portions of cold ethanol
- customto yield
- dry with materialafter drying 8.9 g (53%) of the title compound as crystalline solid
出典と根拠
- ORDレコード
- ord-3b31233088854821acded695b0937130
- 出典データセット
- uspto-grants-2008_05
- 特許番号
- US07371751B2
反応ノート
読み込み中…