Hydrazine → HCID 17990173、化合物

HRID 2222229ノート

反応式

HRID 2222229 の反応式
Cl[C:2]1[N:7]([CH2:8][CH:9]2[CH2:11][CH2:10]2)[C:6](=[O:12])[NH:5][C:4](=[O:13])[CH:3]=1.[NH2:14][NH2:15]>C(O)C>[CH:9]1([CH2:8][N:7]2[C:2]([NH:14][NH2:15])=[CH:3][C:4](=[O:13])[NH:5][C:6]2=[O:12])[CH2:11][CH2:10]1

参加物

4

反応物 2

HCID 9321HydrazineHCID 179901746-Chloro-1-cyclopropylmethyluracil

生成物 1

HCID 17990173HCID 17990173、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
82.5 °C

実験手順

6-Chloro-1-cyclopropylmethyluracil (24.34 g, 0.12 mol) was suspended in absolute ethanol (245 mL) under nitrogen. Anhydrous hydrazine (11.69 g, 0.36 mol) was added via syringe in excess, resulting in a clear-yellow solution. The reaction mixture was heated at 80-85° C. for one hour; bright yellow crystals began forming within minutes of the application of heat. The reaction mixture was cooled to room temperature and then in an ice bath, and the crude product collected by filtration. N2H4×HCl was removed by triturating with cold water to give the product as a pale yellow solid, 20.47 g (86%). Mp 221° C. (dec).

後処理

  1. customresulting in a clear-yellow solution
  2. custombright yellow crystals began forming within minutes of the application
  3. temperatureof heat
  4. temperatureThe reaction mixture was cooled to room temperature
  5. filtrationin an ice bath, and the crude product collected by filtration
  6. customN2H4×HCl was removed
  7. customby triturating with cold water

出典と根拠

ORDレコード
ord-5eb0f140a6fa4afd9002c08e665fec3b
出典データセット
uspto-grants-2008_05
特許番号
US07371757B2

反応ノート

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