N,N-dimethyl-m-phenylenediamine → HCID 68527719、化合物
反応式
CS([C:5]1[N:10]=[C:9]2[N:11]([CH3:26])[C:12](=[O:25])[N:13]([C:15]3[CH:20]=[C:19]([N+:21]([O-:23])=[O:22])[CH:18]=[CH:17][C:16]=3[CH3:24])[CH2:14][C:8]2=[CH:7][N:6]=1)(=O)=O.[CH3:27][N:28]([CH3:36])[C:29]1[CH:30]=[C:31]([CH:33]=[CH:34][CH:35]=1)[NH2:32]>CO>[CH3:27][N:28]([CH3:36])[C:29]1[CH:30]=[C:31]([NH:32][C:5]2[N:10]=[C:9]3[N:11]([CH3:26])[C:12](=[O:25])[N:13]([C:15]4[CH:20]=[C:19]([N+:21]([O-:23])=[O:22])[CH:18]=[CH:17][C:16]=4[CH3:24])[CH2:14][C:8]3=[CH:7][N:6]=2)[CH:33]=[CH:34][CH:35]=1参加物
4
反応条件
- 温度
- 130 °C
実験手順
A mixture of 7-methanesulfonyl-1-methyl-3-(2-methyl-5-nitro-phenyl)-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one (148 mg, 0.39 mmol) and 3-dimethylaminoaniline (530 mg, 3.9 mmol) is stirred for 1 hour at 130° C. The mixture is cooled down to room temperature and suspended in methanol. The precipitate is collected and washed with methanol to give 7-(3-dimethylamino-phenylamino)-1-methyl-3-(2-methyl-5-nitro-phenyl)-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one (98 mg, 58%) as a yellow solid.