Ethylvanillin → HCID 87761353、化合物

HRID 2222333ノート

反応式

HRID 2222333 の反応式
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[OH:12])[CH:7]=[O:8])[CH3:2].[CH3:13][O:14][CH2:15][CH2:16][O:17][CH2:18]Cl>>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[O:12][CH2:13][O:14][CH2:15][CH2:16][O:17][CH3:18])[CH:7]=[O:8])[CH3:2]

参加物

3

反応物 2

HCID 8467EthylvanillinHCID 775901-(Chloromethoxy)-2-methoxyethane

生成物 1

HCID 87761353HCID 87761353、化合物収率 91.5%

実験手順

The hydroxyl group of 3-ethoxy-4-hydroxybenzaldehyde (2.0 g) was protected by use of 2-methoxyethoxymethyl chloride (1.5 g) in accordance with (production process 1), to thereby produce 3-ethoxy-4-methoxyethoxymethoxybenzaldehyde (2.8 g, yield: 91%). The thus-produced 3-ethoxy-4-methoxyethoxymethoxybenzaldehyde (2.8 g) and 3,4-dimethoxybenzyl cyanide (2.0 g) were subjected to condensation in accordance with process A of (production process 2), to thereby yield an MEM form of the target product. Subsequently, the protective group was removed from the MEM form in accordance with (production process 3), to thereby produce the target product (1.35 g, yield: 37%).

出典と根拠

ORDレコード
ord-ef4a11869a9b440f990af35d4f78bf0e
出典データセット
uspto-grants-2008_05
特許番号
US07371773B2

反応ノート

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