Hydrochloric Acid → 1-(5-chloro-1H-benzimidazol-2-yl)-1-phenyl-methylamine
反応式
C([NH:4][CH:5]([C:12]1[NH:16][C:15]2[CH:17]=[CH:18][C:19]([Cl:21])=[CH:20][C:14]=2[N:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)(=O)C.Cl>C(O)C>[Cl:21][C:19]1[CH:18]=[CH:17][C:15]2[NH:16][C:12]([CH:5]([NH2:4])[C:6]3[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=3)=[N:13][C:14]=2[CH:20]=1参加物
4
反応条件
- 温度
- 50 °C
実験手順
1.34 g (4.47 mmol) N-acetyl-1-(5-chloro-1H-benzimidazol-2-yl)-1-phenyl-methylamine in 9 ml of ethanol are combined with 18 ml of conc. hydrochloric acid and heated to 50° C. for 2 days. The reaction mixture is evaporated down i. vac. and twice taken up in ethanol and evaporated down again.
後処理
- customThe reaction mixture is evaporated down i
- customevaporated down again
出典と根拠
- ORDレコード
- ord-c31caa2950fc40fb86f8658893843333
- 出典データセット
- uspto-grants-2008_05
- 特許番号
- US07371743B2
反応ノート
読み込み中…